RUMORED BUZZ ON CONOLIDINE ALKALOID FOR CHRONIC PAIN

Most recently, it's been determined that conolidine and the above derivatives act around the atypical chemokine receptor 3 (ACKR3. Expressed in comparable places as classical opioid receptors, it binds to a big range of endogenous opioids. Not like most opioid receptors, this receptor functions as being a scavenger and won't activate a 2nd messenge